Xenobiotic Metabolism: A View through the Metabolometer
نویسندگان
چکیده
منابع مشابه
Xenobiotic metabolism: a view through the metabolometer.
The combination of advanced ultraperformance liquid chromatography coupled with mass spectrometry, chemometrics, and genetically modified mice provide an attractive raft of technologies with which to examine the metabolism of xenobiotics. Here, a reexamination of the metabolism of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), the suspect carcinogen areca alkaloids (ar...
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The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differ...
متن کاملSymbolic Inference of Xenobiotic Metabolism
We present a new symbolic computational approach to elucidate the biochemical networks of living systems de novo and we apply it to an important biomedical problem: xenobiotic metabolism. A crucial issue in analyzing and modeling a living organism is understanding its biochemical network beyond what is already known. Our objective is to use the available metabolic information in a representatio...
متن کاملXenobiotic Metabolism and Gut Microbiomes
Humans are exposed to numerous xenobiotics, a majority of which are in the form of pharmaceuticals. Apart from human enzymes, recent studies have indicated the role of the gut bacterial community (microbiome) in metabolizing xenobiotics. However, little is known about the contribution of the plethora of gut microbiome in xenobiotic metabolism. The present study reports the results of analyses o...
متن کاملXenobiotic metabolism: a look from the past to the future.
The earliest history of xenobiotic metabolism is interwoven with the birth of organic chemistry. In the early 1800s, the belief prevailed that the composition of the human body and indeed, of all living things, was a result of a “vital force” or “internal flame” and that mere mortals were incapable of understanding these workings and would be particularly unable to synthesize constituent compou...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2010
ISSN: 0893-228X,1520-5010
DOI: 10.1021/tx100020p